Medical Nanotechnologies Incorporated

Nanoparticle Functionalization

Drug Delivery

Drug delivery using nanoparticles has the potential to enhance drug bioavailability and enable precision therapeutic targeting. Nanoscale delivery can be administered through a variety of means including aerosol, injection, oral, and transdermal modes. Due to the size of nanoparticles (less than 100 nm), strategies can be devised whereby normal biological entry barriers such as the blood-brain barrier, the highly branched architecture of the lungs and the tight epithelial junctions of the skin can be penetrated. In addition to the penetration of the natural barriers of the human body, the plasma membrane of cells can also be traversed using nanostructured carriers.

Targeted Hyperthermic Therapy

To eliminate side effects of cancer therapy, one approach is to develop a delivery vehicle capable of controlled multimodal treatment that delivers a combination of one or more therapeutic routes directly to the tumor.  Due to their size, nanoparticles have the potential to improve cancer treatment by being able to reach deep into the tumor. Through surface modification techniques using our polymer technology, targeting agents can be attached to nanoparticles, enabling site-specific therapeutic delivery. Finally, nanoparticles, such as those comprised of metallic, magnetic, or carbon nanotube materials, generate heat upon exposure to external electromagnetic radiation. Such nanoparticles can be delivered to tumor cells enabling targeted hyperthermia and even controlled thermoablation to specifically kill the tumor.